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Native curcumins rapid metabolism and low systemic exposure question whether the intracellular concentrations required for epigenetic modulation are physiologically achievable

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10.1101/cshperspect.a008409 117 YoshidaN.LibermanM

Overall survival (OS) was increased to 74% by decreasing the dose of cyclophosphamide to below 200 mg/kg, but the probability of graft rejection (GR) remained high (35%) and event-free survival (EFS) remained low (49%) [80], probably due to inadequate immunosuppression and/or a failure to eradicate the massive erythroid hyperplasia